Extremely high frequency of autoimmune-predisposing alleles in medieval specimens     

Witas HW  Jedrychowska-Dańska K  Zawicki P 《Journal of Zhejiang University. Science. B》2007,8(7):512-514

The precise etiology and reasons for the increase in incidence of autoimmune disorders still remain unclear, and although both genetic and environmental factors have been proven to shape individual predisposition, it is not known which of the factors, if not both, is responsible for the boom observed during the last decades. In order to establish whether a higher frequency of autoimmune-predisposing alleles may explain this increase we took advantage of ancient DNA methodology to establish the genetic predisposition, conferred by cytotoxic T lymphocyte associated antigen-4 （CTLA4） ＋49A/G and human leukocyte antigens （HLA） DQBI^57, in population inhabiting Poland in the Middle Ages. After successful typing of 42 individuals from a 12th-14th＇s century archeological burial site, we found that frequencies of the predisposing alleles in the medieval population were higher than they are at present, suggesting thus that the recently observed incidence increase results most probably from factors of other than genetic nature.  相似文献   

Effect of 12-week-long aerobic training programme on body composition,aerobic capacity,complete blood count and blood lipid profile among young women     

Dorota Kostrzewa-Nowak  Robert Nowak  Zbigniew Jastrz?bski  Aleksandra Zar?bska  Marta Bichowska  Izabela Drobnik-Kozakiewicz  ?ukasz Radzimiński  Agata Leońska-Duniec  Krzysztof Ficek  Pawe? Ci?szczyk 《Biochemia medica : ?asopis Hrvatskoga dru?tva medicinskih biokemi?ara / HDMB》2015,25(1):103-113

Background

Numerous data suggest that aerobic-type exercise improves lipoprotein-lipid profiles, cardiorespiratory fitness and body composition in young women. The aim of this study was to evaluate the biological response to high-low impact aerobic fitness among young women.

Materials and methods

Thirty-four young women aged 22 (19-24) years were divided into three groups: underweight (N = 10), normal weight (N = 12) and overweight (N = 12). Aerobic capacity, anthropometry and body composition together with complete blood count and lipid profile were determined before and after completion of a 12-week-long training period.

Results

The training programme caused a significant decrease in weight (by 4.3 kg, P = 0.003), body mass index (by 1.3 kg/m², P = 0.003), free fat mass (by 2.1 kg, P = 0.002), total body water (by 0.4 kg, P = 0.036), percentage of fat (by 3 percent points, P = 0.002), all analyzed skinfolds thicknesses, as well as the lipid profile in overweight group, and no changes in normal weight group. Significant changes in weight (by 4.2 kg, P = 0.005), body mass index (by 0.9 kg/m², P = 0.005), crus skinfold thickness (by 3.3 mm, P = 0.028), and in maximum oxygen uptake (by 2.49 mL/kg/min; P = 0.047) were observed among underweight women. No change in total blood count was observed in all groups.

Conclusion

Twelve-week-long fitness training programme of two alternating styles (low and high impact) has a beneficial effect on overweight young women.Key words: body composition, physical fitness, overweight, women  相似文献   

Methodology of world clearinghouse activity     

Konrad R. Fiałkowski  Mieczysław R. Muraszkiewicz  Alicja B. Tołwińska 《Information processing & management》1981,17(1):21-25

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Job satisfaction and temperament structure of gifted people     

Małgorzata Siekańska  Andrzej Sękowski 《High Ability Studies》2006,17(1):75-85

This article focuses on the problems of adults who in secondary school were high ability learners. The main point of interest of the research presented here is job satisfaction among gifted people and their temperament structure. The authors are interested whether there exist correlations between the investigated variables both in the entire group of gifted individuals as well as in the subgroup of those gifted in the humanities and in the control group. The research results show that between the group of gifted people and the control group there appear significant differences in vigorousness (VG) and activity (AC). The studied groups differ as to the kind and extent of the fulfilment of expectations concerning professional career. Gifted individuals, in comparison to the control group, are more satisfied with their jobs.  相似文献   

Nouvelles tendances dans L'appreciation des taches de l'enseignement elementaire     

Wincenty Okoń 《International Review of Education/Internationale Zeitschrift für Erziehungswissenschaft/Revue internationale l'éducation》1969,15(1):42-56

Sans résumé

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New trends in defining the functions of elementary education

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Neue Tendenzen in der Beurteilung der Aufgaben des Elementarunterrichts

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Dynamics of a periodically driven chain of coupled nonlinear oscillators     

Paweł Fritzkowski  Roman Starosta  Grażyna Sypniewska-Kamińska  Jan Awrejcewicz 《浙江大学学报(A卷英文版)》2017,18(7):497-510

A 1D chain of coupled oscillators is considered, including the Duffing-type nonlinearity, viscous damping, and kinematic harmonic excitation. The equations of motion are presented in a non-dimensional form. The approximate equations for the vibrational amplitudes and phases are derived by means of the classical averaging method. A simple analysis of the resulting equations allows one to determine the conditions for the two basic synchronous steady-states of the system: the in-phase and anti-phase motions. The relations between the required excitation frequency and the natural frequencies of the abbreviated (linear) system are discussed. The validity of these predictions is examined by a series of numerical experiments. The effect of the model parameters on the rate of synchronization is analyzed. For the purpose of systematic numerical studies, the cross-correlation of time-series is used as a measure of the phase adjustment between particular oscillators. Finally, some essential issues that arise in case of the mechanical system with dry friction are indicated.  相似文献   

Overweight and obesity versus concentrations of VEGF-A,sVEGFR-1, and sVEGFR-2 in plasma of patients with lower limb chronic ischemia     

Radosław Wieczór  Anna Maria Wieczór  Grażyna Gadomska  Katarzyna Stankowska  Jacek Fabisiak  Karol Suppan  Grzegorz Pulkowski  Jacek Budzyński  Danuta Rość 《Journal of Zhejiang University. Science. B》2016,17(11):842-849

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Propolis modulates vitronectin, laminin, and heparan sulfate/heparin expression during experimental burn healing     

Pawe? Olczyk  Katarzyna Komosińska-Vassev  Katarzyna Winsz-Szczotka  Ewa M. Ko?ma  Grzegorz Wisowski  Jerzy Stojko  Katarzyna Klimek  Krystyna Olczyk 《Journal of Zhejiang University. Science. B》2012,13(11):932-941

Objective

This study was aimed at assessing the dynamics of vitronectin (VN), laminin (LN), and heparan sulfate/heparin (HS/HP) content changes during experimental burn healing.

Methods

VN, LN, and HS/HP were isolated and purified from normal and injured skin of domestic pigs, on the 3rd, 5th, 10th, 15th, and 21st days following thermal damage. The wounds were treated with apitherapeutic agent (propolis), silver sulfadiazine (SSD), physiological salt solution, and propolis vehicle. VN and LN were quantified using an immunoenzymatic assay and HS/HP was estimated by densitometric analysis.

Results

Propolis treatment stimulated significant increases in VN, LN, and HS/HP contents during the initial phase of study, followed by a reduction in the estimated extracellular matrix molecules. Similar patterns, although less extreme, were observed after treatment with SSD.

Conclusions

The beneficial effects of propolis on experimental wounds make it a potential apitherapeutic agent in topical burn management.  相似文献   

Flipped spotters learning model: An innovative student activity-based strategy. A preparation tool for anatomy practical examinations in medical education     

Marcelina Łopińska  Jerzy Stanisław Gielecki  Anna Żurada 《Anatomical sciences education》2022,15(5):886-897

The flipped spotters learning model is a modern student activity-based and learner-centered method in medical education. The aim of the study was to determine if the flipped spotters learning model improves students' learning. Participants were 1214 medical students of Polish (PD) and English (ED) divisions between 2013 and 2019 academic years at the University of Warmia and Mazury in Olsztyn, Poland. They were divided into a traditional group (control group) and a flipped spotters learning group (treatment group). Each flipped spotters learning group was asked to label anatomical structures on various specimens according to the structures name list prepared by the teacher on the multiple stations. The flipped spotters learning group leaders were instructed to take pictures with the appropriately marked structures on each of the human body prosections. After completion of the class, each flipped spotters team received photos for evaluation. In the flipped spotters learning model, the students strengthened their skills and knowledge by matching specimens independently as a form of practical laboratory activities. Students' performance in gross anatomy practical examinations between the group utilizing the flipped spotters learning model, and the group with the traditional teaching model was compared. Students participating in the treatment group achieved, on average 9.9 percentage points higher among PD students, and 13.0 percentage points higher among ED students than the control group in all nine practical examinations (the effect size ranging from 0.47 to 0.95). The results suggest the positive impact of flipped spotters model on improving student's performance in the practical examinations.  相似文献   

Trust and Mistrust in Sources of Scientific Information on Climate Change and Vaccines     

Rowland  Jussara  Estevens  João  Krzewińska  Aneta  Warwas  Izabela  Delicado  Ana 《Science & Education》2022,31(5):1399-1424

Science & Education - Public trust in science and expertise remains a contentious issue. When public trust is analysed, it often simplifies a complex process of information retrieval and...  相似文献